Milan will be without Samu Castillejo when they take on a Lazio team missing suspended duo Felipe Caicedo and Ciro Immobile on Saturday.
Castillejo suffered a hamstring injury during the 2-2 draw with SPAL on Wednesday and will undergo further evaluation in a week, meaning the Spanish winger will also miss the upcoming home game against Juventus.
His absence is a further blow for Milan coach Stefano Pioli after seeing his team drop two points against a side sitting in the relegation zone in midweek, hardly ideal preparations for a meeting with opponents occupying second spot in the table.
Lazio are hindered themselves by both top-scorer Immobile and fellow forward Caicedo missing the Stadio Olimpico clash. However, Pioli is aware of the dangers posed by Joaquin Correa, as he scored the decisive goal in a 2-1 win over Milan back in November.
"Lazio are strong, they come from two important comebacks," Pioli told the media on Friday. "Immobile and Caicedo will be missed, but they have Correa. It will be a very complex game, especially from a tactical point of view.
"We are a different team [from the last meeting], many things have changed. We will have to be compact, smart and understand the key moments of the game.
"Lazio are a complete team. They are strong, but we also have to have confidence in ourselves."
Zlatan Ibrahimovic made his first appearance since the Italian season resumed during the game with SPAL, coming on as a 65th-minute substitute on his return from injury.
The Swedish striker could be set to play a greater part in proceedings against Lazio, Pioli revealed.
Asked about Ibrahimovic's fitness, he replied: "Maybe he doesn't know how many minutes he has in his legs. His condition will improve playing, on Thursday he did a good workout. I hope I can put more minutes in his legs on Saturday."
Lazio have rallied after falling behind to beat Fiorentina and Torino in their previous two league outings, leaving them four points behind leaders Juve in the title race.
"We are getting used to living with problems during this period," Lazio coach Simone Inzaghi told the media. "I'm convinced the team can play an excellent game regardless of formation and players.
"These guys are having a great season, I'm proud to be their coach. There are seven games left in the championship, we must take one game at a time."