Sergio Aguero is to travel to Barcelona for an assessment on his damaged left knee, Manchester City have confirmed.
The Argentina striker was in discomfort after winning a first-half penalty in Monday's 5-0 victory over Burnley and the injury appeared to be aggravated in a challenge with Clarets skipper Ben Mee.
Following the game, City boss Pep Guardiola admitted it did not "look good" for Aguero, who was struggling with the injury in training prior to the Premier League's resumption.
Original reports suggested Aguero had damaged his left meniscus and would require surgery.
City stopped short of confirming the 32-year-old will go under the knife, but it remains a distinct possibility.
"@aguerosergiokun suffered damage to his left knee in our recent 5-0 win over Burnley," City posted on Twitter.
"The striker will now travel to Barcelona to see Dr Ramon Cugat for further examination.
"Everyone at City wishes Sergio the best with his recovery."
Aguero later took to Twitter to update fans, posting: "The scans I did this morning have confirmed that I have damaged my left knee.
"It's a pity but I'm in good spirits and so focused to come back as soon as possible. Thank you very much for all your messages!"
It remains to be seen if City's top scorer will have any further involvement in the side's Premier League and FA Cup campaigns.
City also face a nervy wait to see if their talismanic striker will be available for the resumption of the Champions League in August.
Guardiola's men still have to complete their last-16 tie against Real Madrid, which they lead 2-1 from the first leg.
Should they progress, City will compete in an eight-team straight-knockout tournament in Lisbon to determine this season's Champions League victors.