FIFA has warned that any player competing in a European Super League would become ineligible to take part in World Cups, European Championships or the Champions League.
Amid speculation that the biggest clubs from the Premier League, LaLiga, Serie A, Bundesliga and Ligue 1 are keen on forming a breakaway competition, football's world governing body has taken a strong stance against such ideas.
A joint statement from FIFA and the six continental federations read: "In light of recent media speculation about the creation of a closed European 'Super League' by some European clubs, FIFA and the six confederations (AFC, CAF, CONCACAF, CONMEBOL, OFC and UEFA) once again would like to reiterate and strongly emphasise that such a competition would not be recognised by either FIFA or the respective confederation.
"Any club or player involved in such a competition would as a consequence not be allowed to participate in any competition organised by FIFA or their respective confederation.
"As per the FIFA and confederation statutes, all competitions should be organised or recognised by the relevant body at their respective level, by FIFA at the global level and by the confederations at the continental level.
"In this respect, the confederations recognise the Club World Cup, in its current and new format, as the only worldwide club competition, while FIFA recognises the club competitions organised by the confederations as the only club continental competitions.
"The universal principles of sporting merit, solidarity, promotion and relegation, and subsidiarity are the foundation of the football pyramid that ensures football's global success and are, as such, enshrined in the FIFA and confederation statutes.
"Football has a long and successful history thanks to these principles. Participation in global and continental competitions should always be won on the pitch."
It was reported in October that FIFA were hoping to create a closed 18-team tournament that would be dubbed the 'European Premier League'.
However, FIFA president Gianni Infantino said he was "not interested" in the idea and felt the existing Club World Cup had greater potential.
Prior to his resignation as Barcelona president, Josep Maria Bartomeu revealed at a news conference that he had accepted a proposal for the club to join the proposed European Super League.