Liverpool return to the setting of their sixth coronation as European champions on Tuesday, as they face Atletico Madrid at the Wanda Metropolitano in their last-16 first leg.
The Reds beat Tottenham 2-0 at Atletico's ground last year to win the competition for the first time since 2005, having been defeated in the final the previous campaign.
They go into Tuesday's encounter as big favourites due to a combination of their remarkable form and Atletico's well-documented struggles.
Borussia Dortmund and Paris Saint-Germain tussle in Germany in Tuesday's other fixture, with their contest sure to capture the imagination of neutrals given the amount of attacking talent on display.
Ahead of Tuesday's action, we take a look at the key data from both games…
Atletico Madrid v Liverpool
0 - Atletico have never lost at home under Diego Simeone in the Champions League knockout stages (W8 D4). In those 12 games, they have only conceded two goals.
3 - Liverpool, who beat Genk and Salzburg on matchday three and matchday six of the group stage, have never won three consecutive away Champions League games. They last did so in the European Cup back in September 1984 under manager Joe Fagan (five in a row).
10 - Liverpool's Sadio Mane has scored 10 goals in 14 Champions League knockout games since 2017-18. Only Cristiano Ronaldo has been more prolific over that period (11 goals).
3 - Liverpool have always progressed against Spanish opposition in two-legged Champions League ties (3/3): 2-2 on away goals v Barcelona (2006-07, round of 16), 5-0 on aggregate v Real Madrid (2008-09, round of 16), 4-3 v Barcelona (2018-19, semi-finals).
50 - If he plays, this will be Alvaro Morata's 50th Champions League game. Fifty per cent of the Atletico striker's goals in the Champions League have come in the knockout phase (7/14).
Borussia Dortmund v PSG
1 - Dortmund have made it past the Champions League last 16 only once in the past five seasons. That was in 2016-17 under current PSG coach Thomas Tuchel – they were eventually knocked out by Monaco in the quarter-finals.
8 - PSG have reached the Champions League knockout stages for the eighth consecutive season – only Real Madrid (23), Barcelona (16) and Bayern Munich (12) are on a longer run. However, in that time, the French side have never gone past the quarter-finals and have been eliminated in the last 16 in each of the past three seasons.
2 - Two of the three youngest players to have scored three or more goals and delivered three or more assists in the Champions League since last season play for Dortmund: 19-year-old Jadon Sancho (three goals, three assists) and 21-year-old Achraf Hakimi (four goals, three assists). The other is PSG's 21-year-old Kylian Mbappe (nine goals, eight assists).
30 - Mbappe has had 30 goal involvements in 30 Champions League games (19 goals, 11 assists). He has scored three goals against BVB, his joint-best record in the Champions League against a single opponent.
22 - Dortmund's previous 22 goals in the Champions League have all come from open play, the longest current run among the remaining sides in the competition.