Eastern
| # | Team | PL | W | D | L | +/- | GD | PTS | Form | Next |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | New England | 34 | 22 | 7 | 5 | 65-41 | 24 | 73 | ||
| 2 | Philadelphia | 34 | 14 | 12 | 8 | 48-35 | 13 | 54 | ||
| 3 | Nashville SC | 34 | 12 | 18 | 4 | 55-33 | 22 | 54 | ||
| 4 | NYCFC | 34 | 14 | 9 | 11 | 56-36 | 20 | 51 | ||
| 5 | Atlanta United | 34 | 13 | 12 | 9 | 45-37 | 8 | 51 | ||
| 6 | Orlando | 34 | 13 | 12 | 9 | 50-48 | 2 | 51 | ||
| 7 | NY Red Bulls | 34 | 13 | 9 | 12 | 39-33 | 6 | 48 | ||
| 8 | DC United | 34 | 14 | 5 | 15 | 56-54 | 2 | 47 | ||
| 9 | Columbus | 34 | 13 | 8 | 13 | 46-45 | 1 | 47 | ||
| 10 | Montreal | 34 | 12 | 10 | 12 | 46-44 | 2 | 46 | ||
| 11 | Inter Miami CF | 34 | 12 | 5 | 17 | 36-53 | -17 | 41 | ||
| 12 | Chicago | 34 | 9 | 7 | 18 | 36-54 | -18 | 34 | ||
| 13 | Toronto | 34 | 6 | 10 | 18 | 39-66 | -27 | 28 | ||
| 14 | Cincinnati | 34 | 4 | 8 | 22 | 37-74 | -37 | 20 |
